Marijuana as medicine
Medical marijuana refers to using the entire raw marijuana plant, or its essential extracts, to treat specific disease symptoms and other disorders. The U.S. Food and Drug Administration has not recognized or approved the marijuana or purple weed strains plant as a drug.
However, the scientific study of marijuana's chemicals, called cannabinoids, has led to the FDA's approval of two cannabinoid-containing pill-containing medications. As research continues, more drugs may be approved.
Since the marijuana or purple strains plant contains chemicals that can help treat various diseases and symptoms, many argue that it should legalize its use for medicinal purposes. More and more states have legalized marijuana, slactavis for therapeutic use Watermelon Sauce.
The FDA requires that rigorous studies (clinical trials) be conducted on hundreds and even thousands of people to determine the benefits and risks of a possible drug. To date, researchers have not worked enough large-scale clinical trials to show that the help of the marijuana plant (not its cannabinoid ingredients) outweigh the risks in patients for whom treatment is indicated.
Cannabinoids are chemicals associated with delta-9-tetrahydrocannabinol (THC), the primary psychoactive ingredient in marijuana that alters the mind and generates the high or "high" in those who consume it 1-Test Cyp. The marijuana plant contains more than 99 cannabinoids. Furthermore, both illegal manufacturers and scientists have produced many laboratory cannabinoids. Some of these cannabinoids are very powerful and cause serious health effects once used unsuitably.
There is a growing interest in the chemical marijuana cannabidiol (CBD) to treat certain diseases such as childhood epilepsy, a disorder that causes violent seizures in children. Therefore, scientists have been significantly growing marijuana plants and producing CBD in oil for therapeutic purposes. These drugs are not famous for recreational use because they do not produce euphoria or affect the mind.
The body also produces its cannabinoid chemicals. These compounds play a role in regulating pleasure, memory, thought, concentration, motor coordination, time perception, appetite and pain, in addition to the senses (taste, touch, smell, hearing and sight).
The two main cannabinoids of the marijuana plant that are of medicinal interest are THC and CBD.
THC can increase appetite and reduce nausea. It can also reduce pain, inflammation (swelling and redness), and problems with muscle control.
Unlike THC, CBD is a cannabinoid that does not cause a high or "high," which does not alter the mind. It can help reduce pain and inflammation control epileptic seizures, and may even use it to treat mental illness and addictions.
Many researchers, including researchers funded by the National Institutes of Health (NIH), continue to explore the potential uses of THC, CBD, and other cannabinoids for therapeutic purposes Buy Ecstasy 250mg Pills Online.
The FDA approved a liquid CBD-based medication called Epidiolex ® to treat two forms of severe childhood epilepsy, Dravet syndrome, and Lennox-Gastaut syndrome.
For example, recent animal studies have shown that marijuana extracts can help destroy specific cancer cells and reduce others' size. Results from a rodent cell culture study suggest that purified extracts from the entire marijuana plant may slow cancer cells' growth from one of the most severe types of brain tumors. Research with mice showed that treatment with purified extracts of THC and CBD, when used in conjunction with radiation therapy, increases radiation effectiveness in killing cancer. 3
Scientists are also conducting clinical and preclinical trials with marijuana and its extracts to treat symptoms of disease and other disorders, such as:
conditions that affect the immune system, including:
HIV AIDS
multiple sclerosis (M.S.), which causes gradual loss of muscle control
inflammation
pain
seizures
drug use disorders
mental disorders
Two FDA-approved medications, dronabinol, blue cheese strain and nabilone, contain THC. These are treatments for nausea caused by chemotherapy and increased appetite in patients who have experienced extreme weight loss due to AIDS. Ongoing research could lead to the discovery of other drugs.
The United Kingdom, Canada, and several European countries have approved (Sativex®), a mouth spray that contains THC and CBD. It is used to treat muscle control problems caused by multiple sclerosis, but it does not have FDA approval.
Epidiolex, a liquid medication derived from CBD for treating certain forms of childhood epilepsy, is being studied in clinical trials but has not yet been approved by the FDA.
Points to remember
Medical marijuana online refers to using the entire raw marijuana plant or its essential extracts to treat diseases and other disorders.
The U.S. Food and Drug Administration has not recognized or approved the marijuana plant as a drug Golden Shrooms Raw Chocolate Bliss.
However, scientific studies of the chemicals called cannabinoids found in marijuana have led to the FDA approval of two pill-based medications used to treat nausea and increase appetite.
Cannabinoids are chemicals related to delta-9-tetrahydrocannabinol (THC), the primary psychoactive ingredient in marijuana.
The two main cannabinoids of the marijuana plant that are of medicinal interest are THC and cannabidiol (CBD).
The body also produces its cannabinoid chemicals 10 Reasons Why Gold CBD Oil is Better Than Black. Scientists are conducting preclinical and clinical trials with marijuana and its extracts to treat the symptoms of disease and other disorders.
Suppose any parameter within the medical practice with cannabinoids raises more doubts for clinicians and patients and their families, which is undoubtedly the dosage issue.
Usually, in medicine, the dosage of a drug is calculated by the weight of the patient, using as parameters to calculate the final dose to be administered:
The minimum or a maximum dose of the medicine to be administered per kilogram of the patient's weight at each intake or over 24 hours when we speak of age pediatric, or by standardized dose for a weight of 70 kgs, if we talk of adult patients, the latter being able to vary slightly according to the individual's actual weight or according to the dosage to be applied (ibuprofen, for example, can be administered in doses of 400 mg every 8 hours or 600 mg every 12 hours, in both cases, the total daily amount is 1200 mg).
For example, the dose of paracetamol for a child varies between 10-15 mg/kg/dose up to a stipulated maximum of 80 mg/kg/day, where 10 mg/kg would be the minimum dose per dose, 15 mg/kg would be the maximum dose per dose. 80 mg/kg would be the maximum daily dose, that is, the maximum that could be administered to a child in 24 hours. In adults, doses of 500 mg per dose have been used, although for some years, the use of 1000 mg (1 gram) of paracetamol per dose has been generalized, and a maximum daily dose of 4 g can be administered.
All these parameters, commonly used in medicine, are defined after much pharmacological research and after much clinical practice. The exposure in the previous paragraph for the case of paracetamol applies to the vast majority of drugs that are used today. The doses used Canna Clique THC Cherry Glo Extract Green Crack will depend on the individual's weight, in children, and an amount standardized in adults.
None of this is applicable when we use cannabis for medicinal purposes. I will present some interesting points that will help the reader understand dosing's complexity in a standardized way when we talk about cannabis.
The vast majority of studies have been conducted since the first human THC trials, in which perfectly quantified doses of cannabinoids have been used, have been undertaken with isolated THC. In the case of an isolated molecule, THC only, whose active ingredient name is dronabinol and whose commercial name is Marinol ®, has not had excellent efficacy results in the studies in which it has been used. On the other hand, it has presented a significant prevalence of side effects, especially at the psychological level. THC is better tolerated when accompanied by other cannabinoids than when it is used as monotherapy as a single molecule. The starting doses used in these studies usually vary between 2.5 mg and 10 mg (sometimes up to 20 mg) of THC per dose, depending on the study's objective. Doses of 2.5 mg are usually used in the elderly and children, although, curiously, children have a greater tolerance to the psychoactive effects of cannabis than adults. The lower density of CB1 receptors explains this in immature brains about adult brains.
But the reality of the clinical practice, of the patients' day-to-day, is quite different since the Marinol ® (THC) is used in a minimal proportion if we compare it with the herbal form, the Sativex ®, or the cannabis edibles.
For the same reasons, nabilone, whose trade name is Cesamet ® and a synthetic derivative of THC with a potency ten times greater than this, presents today a petite reality of use compared to other accessible sources cannabinoids. Economical, and above all, practical.
After Marinol and Cesamet, we find Sativex ®, a sublingual spray in which each administration (spray) releases a dose of 2.7 mg of THC together with 2.5 mg of CBD into the oral mucosa. The average amount in clinical trials with patients with multiple sclerosis is eight sprays per day (21.6 mg of THC and 20 mg of CBD per day), although doses higher than 12 sprays per day (32.4 mg of THC are not recommended. and 30 mg of CBD a day). On the other hand, it is recommended to apply the product in two doses according to the Spanish Agency of Medicines and Health Products tables. These doses are never the same, always administered a higher dose at night than in the morning. If this, we add that THC has a different bioavailability than CBD.
To describe a more graphic example of THC and Cbd's different bioavailability, some children with drug-resistant epilepsy manage to maintain adequate CBD levels in the blood to control their symptoms for 24 hours with a single administration per day. While with THC, To achieve this same control of symptoms in cancer patients, two daily doses of capsules developed in Israel are necessary, containing a formulation that converts THC into a "prolonged release" substance.
When we talk about afghan kush, we are talking about a substance that bases its multifaceted therapeutic potential because of the different combinations of cannabinoids and terpenoids. We will have a product more suitable for one or another pathology. Thus, we have ideal varieties for insomnia or anxiety problems, while at the other extreme, we find types with a powerful euphoric and antidepressant effect. This variability in impact is not exclusively due to the different combinations of cannabinoids but the combination of these cannabinoids with the other terpenoids present in each variety. The number of combinations between cannabinoids and terpenoids means that when we talk about medicinal cannabis, we are not talking about just one type of "medicine."
This is where the main problem of dosing with cannabis lies ... 5 mg of THC administered by using a pure Sativa variety with a high concentration of the limping terpenoid will never cause. The same effects as 5 mg THC assisted—using a pure Indica variety with a high concentration of the pinene terpenoid. That is why that cannot dose cannabis like the rest of the drugs. To further curl the curl to the above, we must add each individual's genetic variability since the same 5 mg of a variety will not produce the same effect applied to two different individuals. However, the product is the same.
Treatment Individualization
To find the appropriate dose for each individual, the protocol will always be the same: Start with low doses and gradually increase until you find the amount that improves the individual's symptoms. Without the intensity of the side effects limiting therapeutic adherence to treatment, or that is, the one with the most efficient balance between improvement of symptoms/power of side effects. For this, it is important to invest enough time in finding this balance. Too rapid increases in doses will cause side effects that will often lead to the patient's rejection of the treatment. In contrast, if the dose increase is excessively long in time, the lack of effectiveness will cause the patient to abandon the treatment before the apparent lack of energy.
This will be done starting with low doses to increase gradually and at an adequate rate until the optimal amount is found for each individual, considering that this optimal dose will be defined by the balance between improvement of symptoms to side effects by the patient. That will also depend significantly on both the type of product and the route of administration used.
